MRC Toxicology Unit 1 article published in JoVE Cancer Research Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients Giuditta Viticchié1, Ian Powley1, Constantinos Demetriou1, James Cooper1, Michael Butterworth1, Meeta Patel1, Naila Abid1, Gareth Miles1, Lynne Howells1, Howard Pringle1, Marion MacFarlane2, Catrin Pritchard1 1Leicester Cancer Research Center, University of Leicester, 2MRC Toxicology Unit This paper describes methods for the generation, drug treatment, and analysis of patient-derived explants for assessing tumor drug responses in a live, patient-relevant, preclinical model system.
