CN Bio Innovations Ltd 1 article published in JoVE Biology Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro Ovidiu Novac1, Raul Silva1, Lucy-May Young1, Kim Lachani1, David Hughes1, Tomasz Kostrzewski1 1CN Bio Innovations Ltd Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.
