Politecnico di Torino 1 article published in JoVE Bioengineering Bioinspired Soft Robot with Incorporated Microelectrodes Ting Wang1,2, Bianca Migliori1,3, Beatrice Miccoli1,4, Su Ryon Shin1 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 2School of Medicine, Jiangsu University, 3Tech4Health and Neuroscience Institutes, NYU Langone Health, 4Department of Electronics and Telecommunication, Politecnico di Torino A bioinspired scaffold is fabricated by a soft photolithography technique using mechanically robust and electrically conductive hydrogels. The micropatterned hydrogels provide directional cardiomyocyte cell alignment, resulting in a tailored direction of actuation. Flexible microelectrodes are also integrated into the scaffold to bring electrical controllability for a self-actuating cardiac tissue.