UMC Groningen 1 article published in JoVE Developmental Biology Large-scale Scanning Transmission Electron Microscopy (Nanotomy) of Healthy and Injured Zebrafish Brain Jeroen Kuipers1, Ruby D. Kalicharan1, Anouk H. G. Wolters1, Tjakko J. van Ham*2, Ben N.G. Giepmans*1 1Cell Biology, UMC Groningen, 2Clinical Genetics, Erasmus MC Rotterdam Large-scale 2D electron microscopy (EM), or nanotomy, is the tissue-wide application of nanoscale resolution EM. Here we describe a universal method for nanotomy applied to investigate the zebrafish larval brain in health and upon non-invasive brain injury.
