Phospholamban Foundation 1 article published in JoVE Medicine Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model Olympia Bikou1, Roger J. Hajjar2, Lahouaria Hadri1, Yassine Sassi1 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2Phospholamban Foundation This protocol describes the induction of pulmonary hypertension (PH) in mice based on the exposure to hypoxia and the injection of a VEGF receptor antagonist. The animals develop PH and right ventricular (RV) hypertrophy 3 weeks after the initiation of the protocol. The functional and morphometrical characterization of the model is also presented.
