F. Hoffmann-La Roche, Ltd 2 articles published in JoVE Behavior An Objective and Child-friendly Assessment of Arm Function by Using a 3-D Sensor Xing Chen1, Detlef Wolf1, Juliane Siebourg-Polster2, Christian Czech3, Ulrike Bonati4,5, Dirk Fischer4,5, Omar Khwaja6, Martin Strahm1 1Data Science, Roche Pharmaceutical Research and Early Development Informatics, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., 2Translational Technologies and Bioinformatics, Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., 3Biomarker Experimental Medicine, Neuroscience, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd., 4 An objective measure of muscle functions is challenging especially in children. Based on a commercially available digital 3-D sensor, a child-friendly gaming test was developed to assess upper limb function for clinical trials. Medicine Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres Shannon Bunker1, Joanna Holeniewska1, Sauparnika Vijay2, Annegret Dahlmann-Noor2,3, Peng Khaw2,4, Yin-Shan Ng5, David Shima1,6, Richard Foxton1 1Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, 2University College London Institue of Ophthalmology, 3Moorfields Eye Hospital, 4NIHR Biomedical Research Centre, Moorfields Eye Hospital, 5Schepens Eye Research Institute, Harvard Medical School, 6Hoffman-La Roche We present a method for inducing elevated intraocular pressure (IOP), by injecting magnetic microspheres into the rat eye, to model glaucoma. This leads to strong pressure rises, and extensive neuronal death. This protocol is easy to perform, does not require repeat injections, and produces stable long-lasting IOP rises.
