Na Homolce Hospital 2 articles published in JoVE Medicine Translational Rabbit Model of Chronic Cardiac Pacing Vinisha Somaya1, Michaela Popkova1, David Janak2,3, Ilona Princova2,4, Mikulas Mlcek2, Jan Petru1, Petr Neuzil1, Otomar Kittnar2, Pavel Hala1 1Department of Cardiology, Na Homolce Hospital, 2Department of Physiology, First Faculty of Medicine, Charles University, 3Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University, 4Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies. Medicine Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine Pavel Hála1,2, Mikuláš Mlček1, Petr Ošťádal1,2, David Janák1,3, Michaela Popková1, Tomáš Bouček1, Stanislav Lacko1, Jaroslav Kudlička1, Petr Neužil1,2, Otomar Kittnar1 1Department of Physiology, First Faculty of Medicine, Charles University, 2Department of Cardiology, Na Homolce Hospital, 3Department of Cardiovascular Surgery, Second Faculty of Medicine, Charles University Here, we present a protocol to produce tachycardia-induced cardiomyopathy in swine. This model represents a potent way to study the hemodynamics of progressive chronic heart failure and the effects of applied treatment.
