3 articles published in JoVE
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma Jan Hagemann*1, Christian Jacobi*2, Sabine Gstoettner3, Christian Welz4, Sabina Schwenk-Zieger3, Roland Stauber1, Sebastian Strieth1, Julian Kuenzel1, Philipp Baumeister3, Sven Becker1,3 1Department of Otorhinolaryngology, Johannes-Gutenberg University Medical Center, 2Department of Otorhinolaryngology, Technical University of Munich Medical Center, 3Department of Otorhinolaryngology, Ludwig-Maximilian-University Medical Center, 4Department of Otorhinolaryngology, University of Goettingen Medical Center We describe the evolution of a spheroid-based, three-dimensional in vitro model that enables us to test the current standard of experimental therapy regimens for head and neck squamous cell carcinoma on cell lines, aiming at evaluating therapy susceptibility and resistance on primary cells from human specimens in the future.
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke Katharina Schregel1,2, Daniel Behme1, Ioannis Tsogkas1, Michael Knauth1, Ilko Maier3, André Karch4, Rafael Mikolajczyk4,5, Mathias Bähr3, Jörn Schäper6, José Hinz6, Jan Liman3, Marios-Nikos Psychogios1 1Institute of Neuroradiology, University Medical Center Goettingen, 2 The outcome of patients with acute ischemic stroke depends on swift restoration of cerebral blood flow. This protocol aims at optimizing the management of such patients by minimizing peri-procedural timings and rendering the time from hospital admission to reperfusion as short as possible.
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging Kathleen A. Williams1, Yuranny Cabral-Calderin1,3, Carsten Schmidt-Samoa1, Christiane Anne Weinrich1,2, Peter Dechent1, Melanie Wilke1,3,4 1Department of Cognitive Neurology, University Medicine Goettingen, 2Department of Neurology, University Medicine Goettingen, 3German Primate Center, Leibniz Institute for Primate Research, 4DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB) Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations, though its effects are not completely understood. This article describes a safe and reliable setup for applying tACS simultaneously with functional magnetic resonance imaging, which can increase understanding oscillatory brain function and effects of tACS.