3 articles published in JoVE
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping J. Matthijs Biesbroek1, Hugo J. Kuijf2, Nick A. Weaver1, Lei Zhao3, Marco Duering4, Meta VCI Map Consortium, Geert Jan Biessels1 1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 2Image Sciences Institute, University Medical Center Utrecht, 3BrainNow Research Institute, 4Institute for Stroke and Dementia Research, University Hospital, LMU Munich Provided here is a practical tutorial for an open-access, standardized image processing pipeline for the purpose of lesion-symptom mapping. A step-by-step walkthrough is provided for each processing step, from manual infarct segmentation on CT/MRI to subsequent registration to standard space, along with practical recommendations and illustrations with exemplary cases.
Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models Andreas Blutke1, Rüdiger Wanke1 1Institute of Veterinary Pathology at the Centre for Clinical Veterinary Medicine, LMU Munich The practical application and performance of methods for generation of representative tissue samples of porcine animal models for a broad spectrum of downstream analyses in biobank projects are demonstrated, including volumetry, systematic random sampling, and differential processing of tissue samples for qualitative and quantitative morphologic and molecular analyses types.
In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears Wilhelm H. Flatz1, Annika Henneberger2, Maximilian F. Reiser1, Robert Gürkov3, Birgit Ertl-Wagner1 1Department of Radiology, University Hospital, LMU Munich, 2Department of Otorhinolaryngology - Head and Neck Surgery, SLK-Kliniken Heilbronn GmbH, 3Department of Otorhinolaryngology Head and Neck Surgery, Ludwig-Maximilians-University Hospital Munich, German Centre for Vertigo and Balance Disorder To evaluate morphological changes of cranial nerves such as loss of neural structures or swelling of cranial nerves in Menière's Disease (MD) or in healthy persons in vivo, a protocol of evaluation has been developed using magnetic resonance imaging (MRI). Additional MRI-based confirmation of MD was performed.