3 articles published in JoVE
Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice Lars Michel1, Pia Stock1, Christos Rammos1, Matthias Totzeck1, Tienush Rassaf1, Ulrike B. Hendgen-Cotta1 1West German Heart and Vascular Center, Department of Cardiology and Vascular Medicine, Medical Faculty, University Hospital Essen Acute myocardial infarction in mice induces acute but incompletely characterized changes in left ventricular (LV) function. LV catheterization in mice undergoing coronary artery occlusion serves as a novel method for a real-time evaluation of LV function.
Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy Linda Männ1, Anika Klingberg2, Matthias Gunzer2, Mike Hasenberg3 1Department of Translational Skin Cancer Research, University of Duisburg/Essen, 2Institute for Experimental Immunology and Imaging, University of Duisburg/Essen, 3Imaging Center Essen, Electron Microscopy Unit, University Hospital of Essen Here, we describe a light-sheet microscopy approach to visualize the cardiac CD45+ leukocyte infiltrate in a murine model of aseptic fulminant myocarditis, which is induced by the intratracheal diphtheria toxin treatment of CD11c.DTR mice.
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia Sandra Christoph1,2, Alisa B. Lee-Sherick1, Susan Sather1, Deborah DeRyckere1, Douglas K. Graham1 1Department of Pediatrics, University of Colorado Anschutz Medical Campus, 2Department of Bone Marrow Transplantation, University Hospital of Essen Receptor tyrosine kinases are ectopically expressed in many cancers and have been identified as therapeutic targets in acute leukemia. This manuscript describes an efficient strategy for pre-clinical evaluation of tyrosine kinase inhibitors for the treatment of acute leukemia.