3 articles published in JoVE
Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice Vera Buchele1,3, Maike Büttner-Herold2, Tina Vogler1,3, Markus F. Neurath1,3, Kai Hildner1,3 1Department of Internal Medicine 1, University Erlangen-Nürnberg, University Hospital Erlangen, 2Institute of Pathology, Department of Nephropathology, University Hospital Erlangen, 3Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen Here, we present a protocol that describes allogeneic hematopoietic stem cell transplantation and allows repetitive mini-endoscopic evaluations of the distal colon in situ for the presence, characteristics, and severity of colonic inflammation within live mice suffering from intestinal graft-versus-host disease.
The Influence of Liver Resection on Intrahepatic Tumor Growth Hannes H. Brandt1, Valérie Nißler2, Roland S. Croner3 1Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 2Department of Surgery, University Hospital Regensburg, 3Department of Surgery, University Hospital Erlangen A high incidence of tumor recurrence after resection of liver metastases remains an unsolved problem. The illustrated mouse model may be useful to investigate the reasons for such recurrences. It combines a liver resection model with intrahepatic tumor cell injection for the first time.
Surgical Fixation of Sternal Fractures: Preoperative Planning and a Safe Surgical Technique Using Locked Titanium Plates and Depth Limited Drilling Stefan Schulz-Drost1, Pascal Oppel1, Sina Grupp1, Sonja Schmitt1, Roman Th. Carbon2, Andreas Mauerer3, Friedrich F. Hennig1, Thomas Buder4 1Orthopedic and Trauma Surgery, University Hospital Erlangen, 2Pediatric Surgery, University Hospital Erlangen, 3Orthopedic and Trauma Surgery, St.-Theresien Hospital, 4Institute of Anatomy I, University Erlangen-Nuremberg Here we present a method to stabilize sternal fractures by using locked titanium plates in a low profile design. Performing subperiosteal dissection along the sternum while reducing the fracture, using depth limited drilling, and fixing the plates provides a safe surgical way.