University Medical Center of the Johannes Gutenberg-University of Mainz 1 article published in JoVE Neuroscience Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound Axel Neulen*1, Michael Molitor*2,3,4, Michael Kosterhon*1, Tobias Pantel1, Susanne H. Karbach2,3,4, Philip Wenzel2,3,4, Thomas Gaul5, Florian Ringel1, Serge C. Thal5 1Department of Neurosurgery, University Medical Center of the Johannes Gutenberg-University of Mainz, 2Center for Cardiology - Cardiology I, University Medical Center of the Johannes Gutenberg-University of Mainz, 3Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University of Mainz, 4German Center for Cardiovascular Research (DZHK) - Partner site Rhine-Main, 5Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University of Mainz The aim of this manuscript is to present a sonography-based method that allows in vivo imaging of blood flow in cerebral arteries in mice. We demonstrate its application to determine changes in blood flow velocities associated with vasospasm in murine models of subarachnoid hemorrhage (SAH).
