Instituto de Investigaciones Biomedicas (IIBm) Alberto Sols CSIC-UAM

2 articles published in JoVE

• Cancer Research

  
  In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice Julia Ramirez-Moya^1,2, León Wert-Lamas¹, Adrián Acuña-Ruiz^1,2, Miguel A. Zaballos^1,2, Pilar Santisteban^{1,2 1}Instituto de Investigaciones Biomédicas, CSIC-UAM, ²Ciberonc, Instituto de Salud Carlos III This protocol describes xenograft and orthotopic mouse models of human thyroid tumorigenesis as a platform to test microRNA-based inhibitor treatments. This approach is ideal to study the function of non-coding RNAs and their potential as new therapeutic targets.

• Biology

  
  A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection Silvia Murillo-Cuesta*^1,2,3, Néstor Vallecillo*¹, Rafael Cediel^1,2,4, Adelaida M. Celaya^1,2, Luis Lassaletta^3,5, Isabel Varela-Nieto^1,2,3, Julio Contreras^{1,2,4 1}Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, ²Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), ³Instituto de Investigación Sanitaria La Paz (IdiPAZ), ⁴Facultad de Veterinaria, Universidad Complutense de Madrid, ⁵Departmento de Otorrino laringología, Hospital Universitario La Paz Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.