Ecole Nationale Superieure des Mines de Saint-Etienne 4 articles published in JoVE Neuroscience Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice Andrea Slezia*1,5, Christopher M. Proctor*2,3, Attila Kaszas1,4, George G. Malliaras2,3, Adam Williamson1,5 1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus. Bioengineering A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles Usein Ismailov1, Esma Ismailova1, Seiichi Takamatsu2 1Department of Bioelectronics, Ecole Nationale Supérieure des Mines de Saint-Étienne, CMP-EMSE, MOC, 2Graduate School of Frontier Sciences, The University of Tokyo In this paper, we present a protocol to selectively deposit organic materials on textiles, which allows for the direct integration of organic electronic devices with wearables. The fabricated devices can be fully integrated in textiles, respecting their mechanical appearance and enabling sensing capabilities. Engineering Wicking Tests for Unidirectional Fabrics: Measurements of Capillary Parameters to Evaluate Capillary Pressure in Liquid Composite Molding Processes Monica Francesca Pucci1, Pierre-Jacques Liotier1, Sylvain Drapier1 1Department of Mechanics and Materials Processing, George Friedel Laboratory, Mines Saint-Étienne An experimental method to measure geometrical parameters and the apparent advancing contact angles describing capillary wicking in unidirectional synthetic and natural fabrics is proposed. These parameters are mandatory for the determination of the capillary pressures that must be taken into account for liquid composite molding (LCM) applications. Bioengineering Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor Scherrine A. Tria1, Marc Ramuz1, Leslie H. Jimison2, Adel Hama1, Roisin M. Owens1 1Department of Bioelectronics, Ecole Nationale Superieure des Mines, 2Research and Exploratory Development Division, Applied Physics Laboratory, Johns Hopkins University The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.
