Marie Lannelongue Hospital
3 articles published in JoVE
Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography Simon Dang Van1,2,3, Dorothée Brunet1,2,3, Ali Akamkam1,2,3, Benoit Decante1,2, Julien Guihaire1,2,3 1Laboratory of Preclinical Research, Department of Research and Innovation, Groupe Hospitalier Paris Saint Joseph, 2Inserm UMR S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, 3Department of Cardiac Surgery, Marie Lannelongue Hospital A reliable noninvasive approach for functional assessment of the donor heart during normothermic ex situ heart perfusion (NESP) is lacking. We herein describe a protocol for ex situ assessment of myocardial performance using the epicardial echocardiography and conductance catheter method.
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension David Boulate1, Myriam Amsallem1,2, Jean-Baptiste Menager1, Simon Dang Van1, Peter Dorfmuller3, Andrew Connolly4, Alban Todesco5, Benoit Decante1, Elie Fadel1, Francois Haddad2, Olaf Mercier1 1Research and Innovation Unit, RHU BioArt Lung 2020, Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute, Stanford University, 3Department of pathology, Marie Lannelongue Hospital, 4Department of pathology, UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM, Aix-Marseille University We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure pathophysiology.
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet Pierre-Emmanuel Noly1, Julien Guihaire1,4, Matthieu Coblence1, Peter Dorfmüller2,5, Elie Fadel1,3, Olaf Mercier1,3 1Surgical Research Lab, Marie Lannelongue Hospital, 2Department of Pathology, Marie Lannelongue Hospital, 3Department of Thoracic and Vascular Surgery, Marie Lannelongue Hospital, 4Thoracic and Cardiovascular Surgery, University Hospital of Rennes, 5INSERM U999 Paris-Sud University Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.