INSERM U999 Paris-Sud University 1 article published in JoVE Medicine Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet Pierre-Emmanuel Noly1, Julien Guihaire1,4, Matthieu Coblence1, Peter Dorfmüller2,5, Elie Fadel1,3, Olaf Mercier1,3 1Surgical Research Lab, Marie Lannelongue Hospital, 2Department of Pathology, Marie Lannelongue Hospital, 3Department of Thoracic and Vascular Surgery, Marie Lannelongue Hospital, 4Thoracic and Cardiovascular Surgery, University Hospital of Rennes, 5INSERM U999 Paris-Sud University Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.
