The Hebrew University–Hadassah Faculty of Dental Medicine 1 article published in JoVE Bioengineering Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts Doron Cohn Yakubovich1, Wafa Tawackoli2,3,4, Dmitriy Sheyn2,3, Ilan Kallai1, Xiaoyu Da4, Gadi Pelled1,2,3,4, Dan Gazit1,2,3,4, Zulma Gazit1,2,3 1Skeletal Biotech Laboratory, The Hebrew University–Hadassah Faculty of Dental Medicine, 2Department of Surgery, Cedars-Sinai Medical Center, 3Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 4Biomedical Imaging Research Institute, Cedars-Sinai Medical Center Implantation of autologous and allogeneic bone grafts constitute accepted approaches to treat major craniofacial bone loss. Yet the effect of graft composition on the interplay among neovascularization, cell differentiation and bone formation is unclear. We present a multimodal imaging protocol aimed to elucidate the angiogenesis-osteogenesis interdependence at the graft proximity.
