Universita degli studi e-Campus 1 article published in JoVE Bioengineering Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study Monica Ferro*1, Franca Castiglione*1, Carlo Punta1, Lucio Melone1,2, Walter Panzeri3, Barbara Rossi4, Francesco Trotta5, Andrea Mele1 1Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 2Università degli studi e-Campus, 3ICRM, CNR - Consiglio Nazionale delle Ricerche, 4Elettra Sincrotrone Trieste, 5Department of Chemistry, University of Torino The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in detail.
