Universit degli Studi di Firenze 1 article published in JoVE Biology A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts Kawtar Arizkane1,2,3, Kevin Geistlich1,2,3,4, Laurine Moindrot1,2,3, Emma Risson1,2,3, Sandrine Jeanpierre1,2,3,4, Léa Barral1,2,3, Anaëlle Bobard1,2,3, Giulio Menegazzi5, Thibault Voeltzel1,2,3, Véronique Maguer-Satta1,2,3, Sylvain Lefort1,2,3 1Centre de Recherche en Cancérologie de Lyon, 2Centre de Recherche en Cancérologie de Lyon, 3Université de Lyon, 4Centre Léon Bérard, 5Department of Experimental and Clinical Biomedical Sciences Mario Serio, Università degli Studi di Firenze Here, we describe an easy-to-implement, standardized, microphysiological system that reflects the complexity of the human bone marrow's in vivo structure, providing a pertinent model to finely study a broad range of normal and pathological events.
