2 articles published in JoVE
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development Ellen P. Hart1, Ricardo Alvarez-Jimenez1, Esther Davidse1, Robert Jan Doll1, Adam F. Cohen1, Joop M.A. Van Gerven1, Geert Jan Groeneveld1 1Centre for Human Drug Research (CHDR), Leiden A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery Justin L. Hay1, Pieter Okkerse1, Guido van Amerongen1, Geert Jan Groeneveld1 1Centre for Human Drug Research (CHDR) Human pain models are valuable tools used to assess the analgesic potential of novel compounds and predict their clinical efficacy, especially when used in an integrated manner. Although implementation of these models is complex, with proper execution, the pain models described in this protocol can provide predictive and reliable results.