Sherbrooke Institute of Pharmacology 1 article published in JoVE Bioengineering Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting Simon Beaudoin1, Michel Paquette1, Laurent Fafard-Couture1, Mylene A. Tremblay1, Roger Lecomte1,2,3, Brigitte Guérin1,2,3, Jeffrey V. Leyton1,2,3 1Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center (CIMS), Université de Sherbrooke, 3Sherbrooke Institute of Pharmacology Viral-derived peptides coupled to antibody-conjugates (ACs) is an approach gaining momentum due to the potential of delivering molecular payloads with increased tumor cell accumulation. Utilizing common methods to evaluate peptide conjugation, AC and payload intracellular accumulation, and tumor targeting, this protocol helps researchers during the key initial development phases.
