St. George's University 1 article published in JoVE Bioengineering Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing Michelle Griffin1, Yaami Premakumar2, Alexander Seifalian1, Peter Edward Butler1,3, Matthew Szarko2 1Division of Surgery & Interventional Science, University College London (UCL), 2 Tissue biomechanics is important for maintaining cell shape and function and for determining phenotype. This report demonstrates non-destructive mechanical protocols for characterizing elastic and viscoelastic properties of human soft tissues, which can be directly applied to tissue-engineered substrates to allow a close matching of engineered materials to native tissue.