Claremont McKenna College 1 article published in JoVE Neuroscience Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections Yuu Ohno1, Riley Murphy2, Matthew Choi3, Weijun Ou4, Rachita K. Sumbria4,5 1Henry E. Riggs School of Applied Life Sciences, Keck Graduate Institute, 2Crean College of Health and Behavioral Sciences, Chapman University, 3Keck Science Department, Claremont McKenna College, 4Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, 5Department of Neurology, University of California, Irvine The present protocol describes and compares the procedure to perform a full-region or sub-region of interest analysis of sagittal mouse brain sections to quantify amyloid-beta load in the APP/PS1 transgenic mouse model of Alzheimer's disease.
