TRex Bio 1 article published in JoVE Immunology and Infection Xenograft Skin Model to Manipulate Human Immune Responses In Vivo Madison I. Moss1, Mariela Pauli2, Joshua M. Moreau1, Jarish N. Cohen1, Michael D. Rosenblum1, Margaret M. Lowe1 1Department of Dermatology, UCSF, 2TRex Bio The present protocol describes how to graft human skin onto non-obese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) mice. A detailed description of the preparation of human skin for transplant, preparation of mice for transplant, transplantation of split-thickness human skin, and post-transplantation recovery procedure are included in the report.
