Buck Institute for Research on Ageing 1 article published in JoVE Neuroscience Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein Daniela Elgueta1, Ornella Chovar1, Valentina Ugalde1, Vanesa Sánchez-Guajardo1, Alejandra Catenaccio2, Felipe Court2,3,4, Rodrigo Pacheco1,5 1Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, 2Center for Integrative Biology, Universidad Mayor, 3FONDAP Geroscience Center for Brain Health and Metabolism, 4Buck Institute for Research on Ageing, 5Facultad de Medicina y Ciencia, Universidad San Sebastián This work analyzes the vector dose and exposure time required to induce neuroinflammation, neurodegeneration, and motor impairment in this preclinical model of Parkinson's disease. These vectors encoding the human α-synuclein are delivered into the substantia nigra to recapitulate the synuclein pathology associated with Parkinson's disease.
