Yale New Haven Hospital 1 article published in JoVE Cancer Research Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics Taylor C. Brown1, Norman G. Nicolson2, Joyce Cheng1, Reju Korah1, Tobias Carling1 1Department of Surgery & Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, 2Yale New Haven Hospital This study demonstrates the utility and ease of quantitative cell membrane extension measurement and its correlation to adhesive capacity of cells. As a representative example, we show here that Dickkopf-related protein 3 (DKK3) promotes increased lobopodia formation and cell adhesiveness in adrenocortical carcinoma cells in vitro.
