University of Connecticut Health Center & Connecticut Children's Medical Center 1 article published in JoVE Bioengineering Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue Karolina Chwalek1, Disha Sood1, William L. Cantley1, James D. White1, Min Tang-Schomer2, David L. Kaplan1 1Department of Biomedical Engineering, Tufts University, 2 Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.
