Louisiana State University Health School of Dentistry 1 article published in JoVE Immunology and Infection A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model Junko Yano1, Elizabeth A. Lilly2, Mairi C. Noverr2, Paul L. Fidel1 1Center for Oral and Craniofacial Biology, Louisiana State University Health-School of Dentistry, 2Department of Microbiology and Immunology, Tulane University School of Medicine Here, we present an effective and efficient method for rodent tail vein injections using a uniquely designed warming/restraining device. By streamlining the initiation of vasodilation and restraining processes, this protocol allows accurate and timely intravenous injections of large groups of animals with minimal distress.