RTI International 2 articles published in JoVE Medicine Disposable Dosators Intended for Dry Powder Delivery to Mice Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center Pharmaceutical dry powder development necessitates reliable in vivo testing, often using a murine model. Device technology for accurately and reproducibly delivering dry powder aerosols to mice is restricted. This study presents disposable dosators for pulmonary drug delivery at mouse-relevant doses, aiding initial proof-of-concept research. Medicine Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals Phillip G. Durham1, Shumaila N. Hanif2, Lucia Garcia Contreras2, Ellen F. Young3, Miriam S. Braunstein3, Anthony J. Hickey1 1RTI International, 2Oklahoma University Health Science Center, 3University of North Carolina at Chapel Hill During development of drugs for pulmonary delivery, it is necessary to evaluate pharmacokinetics and efficacy in an animal model. We present a method to build a disposable aerosol dispersion system from of-the-shelf components that can be used to administer intrapulmonary dry powder aerosol to rodents.
