Philips Research North America 2 articles published in JoVE Medicine Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma Aaron Abajian1, Nikitha Murali1, Lynn Jeanette Savic1,2, Fabian Max Laage-Gaupp1, Nariman Nezami1, James S. Duncan3, Todd Schlachter1, MingDe Lin4, Jean-François Geschwind5, Julius Chapiro1 1Department of Radiology and Biomedical Imaging, Yale School of Medicine, 2Department of Diagnostic and Interventional Radiology, Universitätsmedizin Charité Berlin, 3Department of Biomedical Engineering, Yale School of Engineering and Applied Science, 4Philips Research North America, 5Prescience Labs Intra-arterial therapies are the standard of care for patients with hepatocellular carcinoma who cannot undergo surgical resection. A method for predicting response to these therapies is proposed. The technique uses pre-procedural clinical, demographic, and imaging information to train machine learning models capable of predicting response prior to treatment. Medicine Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization Vania Tacher1, MingDe Lin2, Nikhil Bhagat1, Nadine Abi Jaoudeh3, Alessandro Radaelli4, Niels Noordhoek4, Bart Carelsen4, Bradford J. Wood3, Jean-François Geschwind1 1Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Hospital, 2Clinical Informatics, Interventional, and Translational Solutions (CIITS), Philips Research North America, 3Center for Interventional Oncology, Interventional Radiology Section, National Institutes of Health, 4Interventional X-ray, Philips Healthcare Dual-phase cone-beam computed tomography (DP-CBCT) is a useful intraprocedural imaging technique for transarterial chemo-embolization treatment with drug-eluting beads of hepatocellular carcinoma. DP-CBCT has been used to perform three major steps in oncologic interventional radiology: tumor localization (see), navigation and intraprocedural catheter guidance (reach), and intraprocedural evaluation of treatment success (treat).
