Spaulding Hospital Cambridge 1 article published in JoVE Biology Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression J. Andrew Taylor1,2, Can Ozan Tan1,2, J. W. Hamner2 1Department of Physical Medicine and Rehabilitation, Harvard Medical School, 2Cardiovascular Research Laboratory, Spaulding Hospital Cambridge Cerebral perfusion is maintained across a range of pressures via cerebral autoregulation. However, characterizing autoregulation requires prominent pressure fluctuations at regulated frequencies. The described protocol will show how oscillatory lower body negative pressure can generate pressure fluctuations to provide data for projection pursuit regression for quantification of the autoregulatory curve.
