Nevada State College 1 article published in JoVE Chemistry Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach Nicole Benson1, Adam Davis2, Zachary R. Woydziak1 1Department of Physical and Life Sciences, Nevada State College, 2Department of Humanities, Nevada State College The Claisen-Schmidt condensation reaction is an important methodology for the generation of methine-bridged conjugated bicyclic aromatic compounds. Through utilizing a base-mediated variant of the aldol reaction, a range of fluorescent and/or biologically relevant molecules can be accessed through a generally inexpensive and operationally simple synthetic approach.
