New York Langone Medical Center View Institution's Website 4 articles published in JoVE Neuroscience Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability Michael T. Shaw1, Margaret Kasschau2, Bryan Dobbs1, Natalie Pawlak1, William Pau1, Kathleen Sherman1, Marom Bikson3, Abhishek Datta4, Leigh E. Charvet1 1New York University, Langone Medical Center, 2Stony Brook Medicine, 3City College of New York, 4Soterix Medical This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease. Medicine A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation (tDCS) in Multiple Sclerosis (MS) Margaret Kasschau1,2, Kathleen Sherman1,2, Lamia Haider2, Ariana Frontario1,2, Michael Shaw1,2, Abhishek Datta3, Marom Bikson4, Leigh Charvet1,2 1Multiple Sclerosis Comprehensive Care Center, Department of Neurology, NYU Langone Medical Center, 2Department of Neurology, Stony Brook Medicine, 3Soterix Medical, Inc, 4Department of Biomedical Engineering, The City College of New York The goal of this pilot study is to describe a protocol for the remotely-supervised delivery of transcranial direct current stimulation (tDCS) so that the procedure maintains standards of in-clinic practice, including safety, reproducibility, and tolerability. The feasibility of this protocol was tested in participants with multiple sclerosis (MS). Neuroscience Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice Philip M. Brunetti*1, Ralf D. Wimmer*1, Li Liang1, Joshua H. Siegle2, Jakob Voigts2, Matthew Wilson2, Michael M. Halassa1 1The Neuroscience Institute, New York University Langone Medical Center, 2Department of Brain and Cognitive Science, Massachusetts Institute of Technology Understanding the neural substrates of behavior requires brain circuit ensemble recording. Because of its genetic tractability, the mouse offers a model for circuit dissection and disease mimicry. Here, a method of designing and fabricating miniaturized probes is described that is suitable for targeting deep brain structure in the mouse. Immunology and Infection Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy Rachel Lubong Sabado1, Elizabeth Miller2, Meredith Spadaccia1, Isabelita Vengco1, Farah Hasan1, Nina Bhardwaj1 1Cancer Institute, NYU Langone Medical Center, 2Infectious Diseases, NYU Langone Medical Center The most commonly used method for generating large numbers of autologous dendritic cells (DCs) for use in tumor immunotherapy is described. The method uses IL-4 and GM-CSF to differentiate DCs from monocytes. The immature DCs are stimulated to mature and then loaded with antigens before they are injected back into the patient.
