Medicon Pharmaceuticals, Inc 2 articles published in JoVE Medicine A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies Robert A. Honkanen1, Liqun Huang2,3, Basil Rigas2 1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc. This article describes the development of a method to induce acute or chronic dry eye disease in rabbits by injecting concanavalin A to all portions of the orbital lacrimal gland system. This method, superior to those already reported, generates a reproducible, stable model of dry eye suitable for the study of pharmacological agents. Medicine Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits Robert A. Honkanen1, Liqun Huang2,3, Wei Huang1, Basil Rigas2,4 1Department of Ophthalmology, Stony Brook University, 2Department of Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc, 4Department of Preventive Medicine, Stony Brook University A novel approach is presented to induce chronic dry eye disease in rabbits by surgically removing all orbital lacrimal glands. This method, distinct from those previously reported, produces a stable, reproducible model of aqueous deficient dry eye well suited to study tear physiology and pathophysiology and ocular therapeutics.
