New York University Grossman School of Medicine 3 articles published in JoVE Neuroscience Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration Jeffrey D. Messinger1, Max Brinkmann2, James A. Kimble1, Andreas Berlin1, K. Bailey Freund3,4, Gregory H. Grossman5, Thomas Ach*6, Christine A. Curcio*1 1Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham Heersink School of Medicine, 2Department of Ophthalmology, University Hospital of Zurich, 3Vitreous Retina Macula Consultants of New York, 4Department of Ophthalmology, New York University Grossman School of Medicine, 5Advancing Sight Network, 6Department of Ophthalmology, University Hospital Bonn Laboratory assays can leverage prognostic value from the longitudinal optical coherence tomography (OCT)-based multimodal imaging of age-related macular degeneration (AMD). Human donor eyes with and without AMD are imaged using OCT, color, near-infrared reflectance scanning laser ophthalmoscopy, and autofluorescence at two excitation wavelengths prior to tissue sectioning. Cancer Research A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis Arman Alberto Sorin Shadaloey1,2, Alcida Karz1,2, Rana S. Moubarak1,2, Praveen Agrawal1,2, Grace Levinson1,2, Kevin Kleffman1,2, Orlando Aristizabal3,4, Iman Osman2,5, Youssef Z. Wadghiri3,4, Eva Hernando1,2 1Department of Pathology, NYU Grossman School of Medicine, 2Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, 3Department of Radiology, NYU Grossman School of Medicine, 4Preclinical Imaging Core, NYU Grossman School of Medicine, 5Ronald Perelman Department of Dermatology, NYU Grossman School of Medicine This article describes a workflow of techniques employed for testing novel candidate mediators of melanoma metastasis and their mechanism(s) of action. Developmental Biology Is My Mouse Pregnant? High-Frequency Ultrasound Assessment Colin K. L. Phoon1, Mindong Ren2,3 1Department of Pediatrics, New York University Grossman School of Medicine, 2Department of Anesthesiology, New York University Grossman School of Medicine, 3Department of Cell Biology, New York University Grossman School of Medicine High-resolution ultrasound can help streamline experiments requiring timed-pregnant mice by determining the state of pregnancy, gestational age, and pregnancy losses. Presented here is a protocol to illustrate methods to assess mouse pregnancies as well as potential pitfalls (image artifacts) that may mimic pregnancy.
