UPMC Hillman Cancer Center 1 article published in JoVE Cancer Research A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma Phillip Huyett1, Mark Gilbert1, Lijun Liu2, Robert L. Ferris2, Seungwon Kim1 1Department of Otolaryngology, University of Pittsburgh Medical Center, 2University of Pittsburgh Cancer Institute, Hillman Cancer Center Perineural invasion (PNI) is a common feature of head and neck squamous cell carcinoma (HNSCC), conferring lower survival rates. Its mechanisms are poorly understood. Utilizing neurites generated from murine dorsal root ganglia confined to a semisolid matrix, the pathways involved in the PNI of HNSCC cell lines can be investigated.
