Merck Research Labs 1 article published in JoVE Medicine Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis Surya Kumari Vadrevu1, Sharad Sharma1,2, Navin Chintala1,3, Jalpa Patel1, Magdalena Karbowniczek1, Maciej Markiewski1 1Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, 2Merck Research Labs, 3Department of Surgery, Memorial Sloan Kettering Cancer Center Here we describe the model and approach to study functions of pulmonary alveolar macrophages in cancer metastasis. To demonstrate the role of these cells in metastasis, the syngeneic (4T1) model of breast cancer in conjunction with the depletion of alveolar macrophage with clodronate liposomes was used.
