Catalyst Biosciences 1 article published in JoVE Biology Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice Ariadna Carol Illa1,2, Sarah Baumgarten1, Dennis Danielsen1, Karin Larsen3, Torben Elm1, Peter B. Johansen4, Tom Knudsen5, Brian Lauritzen1, Mikael Tranholm6, Carsten D. Ley1 1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.
