CHUL (CHUQ) View Institution's Website 1 article published in JoVE Immunology and Infection An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells Guadalupe Andreani1, Dominic Gagnon1, Robert Lodge1, Michel J. Tremblay1, Dave Richard1 1Infectious Disease Research Center, CHUL (CHUQ), Quebec City, Quebec, Canada We have developed an in vitro malaria-HIV-1 co-infection model to study the impact of Plasmodium falciparum on the HIV-1 replicative cycle in human primary monocyte-derived macrophages. This versatile system can easily be adapted to other primary cell types susceptible to HIV-1 infection.