Institut Universitaire de Cardiologie et de Pneumologie de Quebec 1 article published in JoVE Medicine Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography Samuel Mailhot-Larouche1, Louis Deschênes1, Katherine Lortie1, Morgan Gazzola1, David Marsolais1, David Brunet2, Annette Robichaud2, Ynuk Bossé1 1Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2SCIREQ Scientific Respiratory Equipment Inc. The objective of the present article is to provide a detailed description of the recommended procedures to evaluate respiratory function in conscious mice by double-chamber plethysmography.