Lady Davis Institute for Medical Research 1 article published in JoVE Immunology and Infection Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy Robert J. Scarborough1,2, Kelsey L. Adams1,2, Olivier Del Corpo1,2, Aïcha Daher1, Anne Gatignol1,2,3 1Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical Research, 2Department of Microbiology & Immunology, McGill University, 3Department of Medicine, McGill University Methods to evaluate the efficacy and toxicity of RNA molecules targeting post-integration steps of the HIV-1 replication cycle are described. These methods are useful for screening new molecules and optimizing the format of existing ones.
