Recherche CIUSSS-NIM 1 article published in JoVE Neuroscience Electrocorticographic Recording of Cerebral Cortex Areas Manipulated Using an Adeno-Associated Virus Targeting Cofilin in Mice Julien Dufort-Gervais1, Robbert Havekes2, Valérie Mongrain1,3 1Center for Advanced Research in Sleep Medicine, Recherche CIUSSS-NIM, 2GELIFES, University of Groningen, 3Department of Neuroscience, Université de Montréal This article describes a protocol for the manipulation of molecular targets in the cerebral cortex using adeno-associated viruses and for monitoring the effects of this manipulation during wakefulness and sleep using electrocorticographic recordings.