3 articles published in JoVE
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen Dennis Ma1, Jonathan Collins2, Tomas Hudlicky2, Siyaram Pandey1 1Department of Chemistry and Biochemistry, University of Windsor, 2Chemistry Department and Centre for Biotechnology, Brock University We have synthesized a novel analogue of pancratistatin with comparable anti-cancer activity as native pancratistatin; interestingly, combinatory treatment with tamoxifen yielded a drastic enhancement in apoptotic and autophagic induction by mitochondrial targeting with minimal effect on noncancerous fibroblasts. Thus, JCTH-4 in combination with tamoxifen could provide a safe anti-cancer therapy.
Physiological Experimentation with the Crayfish Hindgut: A Student Laboratory Exercise Ann S. Cooper*1, Bonnie Leksrisawat*1, Allison B. Gilberts*1, A. Joffre Mercier*2, Robin L. Cooper*1 1Department of Biology, University of Kentucky, 2Department of Biological Sciences, Brock University In this report we demonstrate techniques that can be used to investigate the biology of the crayfish hindgut. We show how to dissect a crayfish abdomen and study the associated anatomy, physiology and modulation of activity. The peristaltic activity and strength of contractions are measured using a force transducer.
Recording Behavioral Responses to Reflection in Crayfish A. Joffre Mercier1, Holly Y. May1 1Department of Biological Sciences, Brock University We have developed two methods for studying effects of visual cues on behavior in the absence of tactile and chemical cues. One method involves videotaping responses of crayfish to reflective walls in an aquarium; the other examines effects of visual inputs provided by a live crayfish behind a transparent partition.