National Institute for Occupational Safety and Health

1 article published in JoVE

• Biology

  
  Whole-Body Nanoparticle Aerosol Inhalation Exposures Jinghai Yi^1,2, Bean T. Chen³, Diane Schwegler-Berry³, Dave Frazer³, Vince Castranova³, Carroll McBride¹, Travis L. Knuckles^1,2, Phoebe A. Stapleton^1,2, Valerie C. Minarchick^1,2, Timothy R. Nurkiewicz^{1,2 1}Department of Physiology and Pharmacology, School of Medicine, West Virginia University, ²Center for Cardiovascular and Respiratory Sciences, West Virginia University, ³National Institute for Occupational Safety and Health A whole-body nanoparticle aerosol inhalation exposure facility was constructed for nano-sized titanium dioxide (TiO2) inhalation toxicology studies. This system provides nano-TiO2 aerosol test atmospheres that have: 1) a steady mass concentration; 2) a homogenous composition free of contaminants; and 3) a stable particle size distribution during aerosol generation.