3 articles published in JoVE
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance Emily N. Boice1, Eric J. Snider1,2 1Department of Sensory Trauma, United States Army Institute of Surgical Research, Fort Sam Houston, 2Engineering Processes and Product Development Group, United States Army Institute of Surgical Research, Fort Sam Houston Open globe eye injuries may go untreated for multiple days in rural or military-relevant scenarios, resulting in blindness. Therapeutics are needed to minimize loss of vision. Here, we detail an organ culture open globe injury model. With this model, potential therapeutics for stabilizing these injuries can be properly evaluated.
Integrated Compensatory Responses in a Human Model of Hemorrhage Victor A. Convertino2,3, Carmen Hinojosa-Laborde1,2, Gary W. Muniz1,2, Robert Carter, III1,2 1Tactical Combat Casualty Care Research, JBSA Fort Sam Houston, 2U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, 3U.S. Army Medical Research and Materiel Command, JBSA Fort Sam Houston The purpose of this protocol is to demonstrate the techniques for measuring compensatory responses to reduced central blood volume using lower body negative pressure as a noninvasive experimental model of human hemorrhage which can be used to quantify the total integration of compensatory mechanisms to blood volume deficit in humans.
MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium Whitney A. Greene1, Alberto. Muñiz1, Mark L. Plamper1, Ramesh R. Kaini1, Heuy-Ching Wang1 1Ocular Trauma, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston The microRNA (miRNA) profiles of human induced-pluripotent stem (iPS) cells, retinal pigment epithelium (RPE) derived from human induced-pluripotent stem (iPS) cells (iPS-RPE), and fetal RPE, were compared.