Veterans Affairs Palo Alto Health Care 1 article published in JoVE Medicine A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice Jie Zhang1,2, Fang Fang1,3, Liang Li1, Haoliang Huang1, Hannah C. Webber1, Yang Sun1,4, Vinit B. Mahajan1,4, Yang Hu1 1Department of Ophthalmology, Stanford University School of Medicine, 2Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 3Department of Ophthalmology, Second Xiangya Hospital of Central South University, 4Department of Ophthalmology, Veterans Affairs Palo Alto Health Care Here, we present a protocol to induce ocular hypertension and glaucomatous neurodegeneration in mouse eyes by intracameral injection of silicone oil and the procedure for silicone oil removal from the anterior chamber to return elevated intraocular pressure to normal.
