Charlie Norwood VA Medical Center 1 article published in JoVE Medicine An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis Amy V. Paschall1,2,3, Kebin Liu1,2,3 1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, 2Georgia Cancer Center, Augusta University, 3Charlie Norwood VA Medical Center An orthotopic breast cancer primary tumor model and surgical removal of primary tumor to extend mouse life to generate spontaneous metastasis are described. The tumor growth and progression are monitored and quantified by luciferase fluorescence imaging.
