National Institute of Mental Health 2 articles published in JoVE Behavior Tactile Semiautomatic Passive-Finger Angle Stimulator (TSPAS) Wu Wang1, Jiajia Yang2,4, Yinghua Yu2,3,4, Qiong Wu5,2, Satoshi Takahashi2, Yoshimichi Ejima2, Jinglong Wu6,2 1Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, 2Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3Center for Information and Neural Networks, National Institute of Information and Communications Technology, 4Section on Functional Imaging Methods, National Institute of Mental Health, 5School of Education, Suzhou University of Science and Technology, 6Beijing Institute of Technology Presented is the tactile semiautomated passive-finger angle stimulator TSPAS, a new way to assess tactile spatial acuity and tactile angle discrimination using a computer-controlled tactile stimulus system that applies raised angle stimuli to a subject's passive fingerpad, while controlling for movement speed, distance, and contact duration. Neuroscience Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity Jesse Zhan1, Ruchi Komal1, William T. Keenan2, Samer Hattar1, Diego C. Fernandez1 1Section on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, 2Howard Hughes Medical Institute, Department of Neuroscience, Scripps Research Institute Here we describe two non-invasive methods to chronically control neuronal activity using chemogenetics in mice. Eye-drops were used to deliver clozapine-N-oxide (CNO) daily. We also describe two methods for prolonged administration of CNO in drinking water. These strategies for chronic neuronal control require minimal intervention reducing animals’ stress.
