3 articles published in JoVE
The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer Ligia B. Schmitd1, Min Liu1, Christina S. Scanlon1, Rajat Banerjee1, Nisha J. D’Silva1,2 1Periodontics and Oral Medicine, University of Michigan School of Dentistry, 2Pathology, University of Michigan Medical School Perineural invasion is an aggressive phenotype for head and neck squamous cell carcinomas and other tumors. The chick chorioallantoic membrane model has been used for studying angiogenesis, cancer invasion, and metastasis. Here we demonstrate how this model can be utilized to assess perineural invasion in vivo.
Direct Mouse Trauma/Burn Model of Heterotopic Ossification Jonathan R. Peterson1, Shailesh Agarwal1, R. Cameron Brownley1, Shawn J. Loder1, Kavitha Ranganathan1, Paul S. Cederna1, Yuji Mishina2, Stewart C. Wang1, Benjamin Levi1 1Department of Surgery, University of Michigan Medical School, 2Department of Biologic and Materials Sciences, University of Michigan School of Dentistry An Achilles tenotomy and burn injury model of heterotopic ossification allows for the reliable study of trauma induced ectopic bone formation without the application of exogenous factors.
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache Alexandre F. DaSilva*1,2,3, Thiago D. Nascimento*1, Tiffany Love*3, Marcos F. DosSantos1, Ilkka K. Martikainen1,3, Chelsea M. Cummiford3, Misty DeBoer1, Sarah R. Lucas1, MaryCatherine A. Bender1, Robert A. Koeppe4, Theodore Hall5, Sean Petty5, Eric Maslowski5, Yolanda R. Smith6, Jon-Kar Zubieta3 1Headache & Orofacial Pain Effort (H.O.P.E.), Biological & Materials Sciences Department, University of Michigan School of Dentistry, 2Michigan Center for Oral Health Research (MCOHR), University of Michigan School of Dentistry, 3Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute, University of Michigan, 4PET Physics Section, Division of Nuclear Medicine, Radiology Department, University of Michigan, 53DLab, University of Michigan, 6Department of Obstetrics and Gynecology, University of Michigan In this study, the authors report for the first time a novel 3D-Immersive & Interactive Neuronavigation (3D-IIN) through the impact of a spontaneous migraine headache attack in the μ-opioid system of a patient's brain in vivo.