2 articles published in JoVE
Forming Giant-sized Polymersomes Using Gel-assisted Rehydration Adrienne C. Greene1, Darryl Y. Sasaki2, George D. Bachand1 1Center for Integrated Nanotechnologies, Sandia National Laboratories, 2Biological and Engineering Sciences, Sandia National Laboratories We present a protocol to rapidly form giant polymer vesicles (pGVs). Briefly, polymer solutions are dehydrated on dried agarose films adhered to coverslips. Rehydration of the polymer films results in rapid formation of pGVs. This method greatly advances the preparation of synthetic giant vesicles for direct applications in biomimetic studies.
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing Philip R. Miller1,2, Shelby A. Skoog1, Thayne L. Edwards2, David R. Wheeler2, Xiaoyin Xiao2, Susan M. Brozik2, Ronen Polsky2, Roger J. Narayan1 1Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 2Department of Biosensors and Nanomaterials, Sandia National Laboratories This article details the construction of a multiplexed microneedle-based sensor. The device is being developed for in situ sampling and electrochemical analysis of multiple analytes in a rapid and selective manner. We envision clinical medicine and biomedical research uses for these microneedle-based sensors.